This 35mm presentation is part of the David Lynch season at the Genesis Cinema. You can find the full details here.
Chicago Reader review:
David Lynch's first digital video (2006) is his best and most experimental feature since Eraserhead (1978). Shot piecemeal over at least a year and without a script, this 179-minute meditation builds on Lynch's Mulholland Drive (2001) as a sinister and critical portrait of Hollywood. But it resists any narrative paraphrase, with several overlapping premises rather than a single consecutive plot. Laura Dern plays an actress who's been cast in a new feature, as well as a battered housewife and a hooker; there are also Polish characters and a sitcom with giant rabbits in human clothes. The visual qualities include impressionistic soft-focus colors, expressionistic lighting, and disquietingly huge close-ups. With Justin Theroux, Jeremy Irons, Karolina Gruszka, Harry Dean Stanton, and Grace Zabriskie.
Here (and above) is the trailer.